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Normal function of growth hormone-insulin-like growth factor Ⅰaxis is essential for linear growth after birth. A case of continuous growth with undetectable growth hormone level even under insulinhypoglycemia stimulation was reported. The growth hormone deficiency was due to pituitary stalk interruption combined with deficiency of multiple pituitary hormones. Taken together with reviewed literature, this so-called nongrowth hormone-dependent linear growth was preconditioned by other hormones, especially gonadotropin deficiency,and the unclosed epiphysis.
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Objective To judge the effect of plasma exchange (PE) to the patients with severe hepatopath of nonage according to evaluating the change of the liver function of reserve with 13C-methacetin breath test. Methods There are two groups: the case group and the control group. Each group has 30 patients. The patients in the case group were treated by PE. All the patients received 13C-methacetin breath test at before or one week after treatment. MVmax40, CUM40 and CUM120 were present. At the same time, clinical symptoms, glutamate-pyruvate transaminase (ALT), total bilirubin (TBiL) and prethrombin active (PTA) were observed. Results MVmax40, CUM40, CUM120 and PTA were higher, ALT and TBiL were lower in the case group after treatment (t=4.679, 4.752, 5.048, 5.413, 6.208, 7.413, P=0.000,P<0.01). After a week, MVmax40, CUM40, CUM120 and PTA were higher, ALT and TBiL were lower in the case group than that in the control group (t=2.260, 2.247, 2.476, 4.017, 3.250, 3.658, P<0.05). The total effective rates in the case group and the control group were 83.3 % (25/30) and 43.3 % (13/30),which are significant different(χ2 10.335,P<0.01). Conclusion PE can im-prove the liver reservation functionin the severe hepatopath of nonage.
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Objective To establish a system in which mouse embryonic stem cells (mESCs) differentiate into insulin-secreting cells in vitro. Methods mESCs were cultured to form embryoid bodies(EBs). EBs were cultured in serum-free medium to obtain nestin-positive cells. The selected nestin-positive cells were expanded,then added nicotinamide into the medium to induce the differentiation of nestin-positive cells. Immunochemistry staining and flow cytometry analysis were made on 15th day after induction.Results Flow cytometry analysis revealed that the percentage of nestin-positive cells were different from EBs. The percentage of nestin-positive cells from EBs were higher than those of other diameters. Nestin-positive cells induced by nicotinamide formed islet-like cell clusters. Percentage of insulin-positive cell induced by 10 mmol/L nicotinamide was higher than those induced by 0 mmol/L or 5 mmol/L nicotinamide(P
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Objective To study on the of insulin secretion relations to plasma glucose and the effect of different plasma glucose levels on insulin secretion stimulated by glucose.Methods 98 patients with type 2 diabetes were undergone 75g orally glucose tolerance test(OGTT) and insulin releasing test(IRT) 48hours after stopping administration of oral hypoglycemia agent.The data of plasma levels of glucose and insulin,and the time of peak glucose and insulin and postprandial plasma gluocse and insulin ,the time of peak glucose value,the ratio of maximal glucose to base glucose on base and stimulated insulin secrtion were analyzed statistically.Results The findings demonstrated that plasma glucose of OGTT has relation to base insulin level wihle no significance ,but to stimulate insulin (I max ) of IRT and the ratio of maximal insulin to base insulin(M/B 1).I max and M/B 1 when base glucose level excess 11 1mmol/L were one third of the same index when base glucose level less than 11 1mmol/L(P
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Objective To investigate the incidence of sporadic type of painless thyroiditis (SPT),to analyse its laboratory characteristics, and explore the influence of different treatments on prognosis. Methods 43 patients with SPT, who differentiated from 276 patients with typical thyrotoxicosis, were randomly divided into treatment group (n=22) and control group(n=21).Results the incidence of SPT was 15 58%,the laboratory examinations in SPT differed from those of Graves disease, Plummer's disease and Hoshimotos disease. In treatment group the thyrotoxicosis continued(37 23?4 28) days, the euthyroidism continued(16.43?3.42) days and hypothyroxinemia continued(18.65?6.31)days,only one patients(4.54%) showed that repeated episode and had not left lifelong hypothyroidism; In control group the thyrotoxicosis continued(68 35?8 32) days, the euthyroxinemia continued(31 45?7 23) days and the hypothyroxinemia continued(102 42?21 34) days, 3 patients(14 28%)showed that repeated episodes and two patients(9 52%) left lifelong hypothyroidism in following 1 5 years;Conclusions SPT has less incidence than Grave's disease and more incidence than plummer's disease or Hoshimoto's disease in thyrotoxicosis. The laboratory examination could differentiate each other .The therapy of SPT could control thyrotoxicosis quickly,reduce recurrence rate and lifelong hypothyroidism.
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Objective To investigate the cause, the clinical manifestation, the diagnosis and the treatment of subacute thyroiditis. Methods The medical history, clinical characteristics, laboratory data, nuclear medicine tests and treatment of 76 cases of subactue thyroiditis were analyzed. Results Subacute thyroiditis was more common in women than men, and 76 3% cases with subacute thyroiditis occurred during 30～49 years old. Almost all cases were characterized by enlargement of the thyroid with pain and tenderness, 49 cases of which showed that radioiodine uptake was low with increased serum thyroid hormone levels. 25 cases were treated with prednisone, 23 cases were treated with intrathyroid injection of dexamethasone, 23 cases were treated with intrathyroid injection of dexamethasone and triamcinolone, all recovered well, and 5 cases underwent operation incorrectly. Conclusions Confirmation of subacute thyroiditis should put emphasis on a complete medical history, physical examination and necessary tests. Nuclear medicine tests play an important role in diagnosis of subacute thyroiditis, and the diagnostic drug treatment or fine needle aspiration biopsy may be performed in suspected cases. Glucocorticoid is the best medicine for treating this kind of disease. There is no need for operation therapy of subacute thyroiditis.